IUPHAR/BPS Guide to Pharmacology CITE

Melanocortin receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

Vanni Caruso1, Biao-Xin Chai2, Adrian J. L. Clark3, Roger D. Cone2, Alex N. Eberle4, Sadaf Farooqi5, Tung M. Fong6, Ira Gantz7, Carrie Haskell-Luevano8, Victor J. Hruby9, Kathleen G. Mountjoy10, Colin Pouton11, Helgi Schiöth12, Jeffrey B. Tatro13 and Jarl E. S. Wikberg12
  1. University of Tasmania, Australia
  2. University of Michigan, USA
  3. St. Bartholomew's Hospital, UK
  4. Universitsspital, Switzerland
  5. University of Cambridge, UK
  6. Covance Inc, USA
  7. Merck & Co. Inc., USA
  8. University of Minnesota, USA
  9. University of Arizona, USA
  10. University of Auckland, New Zealand
  11. University of Bath, UK
  12. Uppsala University, Sweden
  13. New England Medical Center Hospital, USA


Melanocortin receptors (provisional nomenclature as recommended by NC-IUPHAR [36]) are activated by members of the melanocortin family (α-MSH, β-MSH and γ-MSH forms; δ form is not found in mammals) and adrenocorticotrophin (ACTH). Endogenous antagonists include agouti and agouti-related protein. ACTH(1-24) was approved by the US FDA as a diagnostic agent for adrenal function test, whilst NDP-MSH was approved by EMA for the treatment of erythropoietic protoporphyria. Several synthetic melanocortin receptor agonists are under clinical development.


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Database links

Melanocortin receptors
Introduction to Melanocortin receptors
            MC1 receptor
            MC2 receptor
            MC3 receptor
            MC4 receptor
            MC5 receptor


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