IUPHAR/BPS Guide to Pharmacology CITE

Glycoprotein hormone receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

Sabine Costagliola1, James A. Dias2, Marvin Gershengorn3, Deborah L. Segaloff4, Axel P.N. Themmen5 and Gilbert Vassart1
  1. Université Libre de Bruxelles, Belgium
  2. New York State Department of Health, USA
  3. National Institutes of Health, USA
  4. University of Iowa, USA
  5. Erasmus University Medical Cente, The Netherlands


Glycoprotein hormone receptors (provisional nomenclature [45]) are activated by a non-covalent heterodimeric glycoprotein made up of a common α chain (glycoprotein hormone common alpha subunit CGA, P01215), with a unique β chain that confers the biological specificity to FSH, LH, hCG or TSH. There is binding cross-reactivity across the endogenous agonists for each of the glycoprotein hormone receptors. The deglycosylated hormones appear to exhibit reduced efficacy at these receptors [120].


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Database links

Glycoprotein hormone receptors
Introduction to Glycoprotein hormone receptors
            FSH receptor
            LH receptor
            TSH receptor


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