IUPHAR/BPS Guide to Pharmacology CITE

Free fatty acid receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

Celia Briscoe1, Andrew Brown2, Nick Holliday3, Stephen Jenkinson4, Graeme Milligan5, Amy E. Monaghan6 and Leigh Stoddart5
  1. Johnson & Johnson Pharmaceutical Research & Development, USA
  2. GlaxoSmithKline, UK
  3. University of Nottingham, UK
  4. Tanabe Research Laboratories, USA
  5. University of Glasgow, UK
  6. University of Edinburgh, UK


Free fatty acid receptors (FFA, nomenclature as agreed by the NC-IUPHAR Subcommittee on free fatty acid receptors [111, 24]) are activated by free fatty acids. Long-chain saturated and unsaturated fatty acids (including C14.0 (myristic acid), C16:0 (palmitic acid), C18:1 (oleic acid), C18:2 (linoleic acid), C18:3, (α-linolenic acid), C20:4 (arachidonic acid), C20:5,n-3 (EPA) and C22:6,n-3 (docosahexaenoic acid)) activate FFA1 [8, 50, 60] and FFA4 receptors [41, 48, 90], while short chain fatty acids (C2 (acetic acid), C3 (propanoic acid), C4 (butyric acid) and C5 (pentanoic acid)) activate FFA2 [9, 62, 86] and FFA3 [9, 62] receptors. The crystal structure for agonist bound FFA1 has been described [108].


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Free fatty acid receptors
Introduction to Free fatty acid receptors
            FFA1 receptor
            FFA2 receptor
            FFA3 receptor
            FFA4 receptor


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