IUPHAR/BPS Guide to Pharmacology CITE
https://doi.org/10.2218/gtopdb/F13/2019.4

Cannabinoid receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database



Mary Abood1, Stephen P.H. Alexander2, Francis Barth3, Tom I. Bonner4, Heather Bradshaw5, Guy Cabral6, Pierre Casellas7, Ben F. Cravatt8, William A. Devane6, Vincenzo Di Marzo9, Maurice R. Elphick10, Christian C. Felder11, Peter Greasley12, Miles Herkenham4, Allyn C. Howlett13, George Kunos14, Ken Mackie15, Raphael Mechoulam16, Roger G. Pertwee17 and Ruth A. Ross18
  1. Temple University, USA
  2. University of Nottingham, UK
  3. Sanofi Synthelabo Recherche, France
  4. National Institute of Mental Health, USA
  5. Indiana University, USA
  6. Medical College of Virginia, USA
  7. Université de Montpellier, France
  8. Scripps Research Institute, USA
  9. CNR Institute of Biomolecular Chemistry, Italy
  10. Queen Mary University of London, UK
  11. Lilly Research Laboratories, USA
  12. AstraZeneca R&D Mölndal, Sweden
  13. North Carolina Central University, USA
  14. National Institutes of Health, USA
  15. University of Washington, USA
  16. Hebrew University, Israel
  17. University of Aberdeen, UK
  18. University of Toronto, Canada


Abstract

Cannabinoid receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Cannabinoid Receptors [107]) are activated by endogenous ligands that include N-arachidonoylethanolamine (anandamide), N-homo-γ-linolenoylethanolamine, N-docosatetra-7,10,13,16-enoylethanolamine and 2-arachidonoylglycerol. Potency determinations of endogenous agonists at these receptors are complicated by the possibility of differential susceptibility of endogenous ligands to enzymatic conversion [4].

There are currently three licenced cannabinoid medicines each of which contains a compound that can activate CB1 and CB2 receptors [104]. Two of these medicines were developed to suppress nausea and vomiting produced by chemotherapy. These are nabilone (Cesamet®), a synthetic CB1/CB2 receptor agonist, and synthetic Δ9-tetrahydrocannabinol (Marinol®; dronabinol), which can also be used as an appetite stimulant. The third medicine, Sativex®, contains mainly Δ9-tetrahydrocannabinol and cannabidiol, both extracted from cannabis, and is used to treat multiple sclerosis and cancer pain.

Contents

This is a citation summary for Cannabinoid receptors in the Guide to Pharmacology database (GtoPdb). It exists purely as an adjunct to the database to facilitate the recognition of citations to and from the database by citation analyzers. Readers will almost certainly want to visit the relevant sections of the database which are given here under database links.

GtoPdb is an expert-driven guide to pharmacological targets and the substances that act on them. GtoPdb is a reference work which is most usefully represented as an on-line database. As in any publication this work should be appropriately cited, and the papers it cites should also be recognized. This document provides a citation for the relevant parts of the database, and also provides a reference list for the research cited by those parts.

Please note that the database version for the citations given in GtoPdb are to the most recent preceding version in which the family or its subfamilies and targets were substantially changed. The links below are to the current version. If you need to consult the cited version, rather than the most recent version, please contact the GtoPdb curators.

Database links

Cannabinoid receptors
http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=13
Introduction to Cannabinoid receptors
http://www.guidetopharmacology.org/GRAC/FamilyIntroductionForward?familyId=13
    Receptors
            CB1 receptor
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=56
            CB2 receptor
            http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=57

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