IUPHAR/BPS Guide to Pharmacology CITE

Apelin receptor (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

Anthony P. Davenport1, Matthias Kleinz1, Tom Lloyd Williams1, Robyn Macrae1, Janet J. Maguire1, Duuamene Nyimanu1 and Peiran Yang1
  1. University of Cambridge, UK


The apelin receptor (nomenclature as agreed by the NC-IUPHAR Subcommittee on the apelin receptor [68]) responds to apelin, a 36 amino-acid peptide derived initially from bovine stomach. apelin-36, apelin-13 and [Pyr1]apelin-13 are the predominant endogenous ligands which are cleaved from a 77 amino-acid precursor peptide (APLN, Q9ULZ1) by a so far unidentified enzymatic pathway [80]. A second family of peptides discovered independently and named Elabela [11] or Toddler, that has little sequence similarity to apelin, is present, and functional at the apelin receptor in the adult cardiovascular system [87, 67]. Structure-activity relationship Elabela analogues have been described [61].


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Apelin receptor
Introduction to Apelin receptor
            apelin receptor


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