IUPHAR/BPS Guide to Pharmacology CITE

Angiotensin receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

Wayne Alexander1, Kenneth E. Bernstein1, Kevin J. Catt2, Marc de Gasparo3, Khuraijam Dhanachandra Singh4, Satoru Eguchi5, Emanuel Escher6, Theodore L. Goodfriend7, Mastgugu Horiuchi8, László Hunyady9, Ahsan Husain10, Tadashi Inagami11, Sadashiva Karnik4, Jacqueline Kemp4, Walter G. Thomas12, Pieter B. M. W. M. Timmermans13, Kalyan Tirupula4, Hamiyet Unal4, Thomas Unger14 and Patrick Vanderheyden15
  1. Emory University, USA
  2. National Institutes of Health, USA
  3. Novartis Institutes for Biomedical Research, Switzerland
  4. Cleveland Clinic Lerner Research Institute, USA
  5. Temple University, USA
  6. Universite de Sherbrooke, Canada
  7. Veterans Administration Hospital Wisconsin, USA
  8. Ehime University, Japan
  9. Semmelweis University, Hungary
  10. University of Alabama at Birmingham, USA
  11. Vanderbilt University, USA
  12. University of Queensland, Australia
  13. Tularik, USA
  14. Christian-Albrechts-Universität zu Kiel, Germany
  15. Vrije Universiteit Brussel, Belgium


The actions of angiotensin II (Ang II) are mediated by AT1 and AT2 receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Angiotensin receptors [61, 152]), which have around 30% sequence similarity. The decapeptide angiotensin I, the octapeptide angiotensin II and the heptapeptide angiotensin III are endogenous ligands. losartan, candesartan, telmisartan, etc. are clinically used AT1 receptor blockers.


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Database links

Angiotensin receptors
Introduction to Angiotensin receptors
            AT1 receptor
            AT2 receptor


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